ABSTRACT
From January 1991 to June 1993, serum PSA according to age were tested by monoclonal radioimmunometric assay using ELSA-PSA 2 kit of CIS industry in 380 healthy men between 30 and 79 years of age who had normal urinalysis, no history of prostate disease and normal prostates on digital rectal examination and transrectal ultrasonography. The mean PSA values according to age were 0.775+/-0.462ng/ml in the 30 to 39-year group, 0.908+/-0.704ng/ml in the 40 to 49-year group, 0.842+/-0.468ng/ml in the 50 to 59-year group, l.393+/-0.942ng/ml in the 60 to 69-year group and 1.737+/-0.937ng/ml in the 70 to 79-year group. The upper limits of PSA (mean+2S.D.) according to age were 1.7ng/ml in the 30 to 39-year group, 2.3ng/ml in the 40 to 49-year group, 1.8ng/ml in the 50 to 59-year group, 3.3ng/ml in the 60 to 69-year group and 3.6ng/ml in the 70 to 79-year group. These results showed that mean PSA and upper limits of PSA increased significantly after 60 years of age(P values<0.01).